Preparation and in vitro release characterization of hot-melt pressure sensitive ad-hesive transdermal patch of progesterone

VernacularTitle:黄体酮热熔压敏胶透皮贴剂的制备及其体外释药性能研究
Author: Hong TAO ¹ ; Wenwen CHEN ; Xiaoli GAO
Author Information

1. 新疆医科大学
Keywords: progesterone; HM PSA; percutaneous penetration; IPM
From: Journal of Pharmaceutical Practice 2016;(1):44-47
CountryChina
Language:Chinese
Abstract: Objective To prepare hot‐melt pressure sensitive adhesive (HMPSA) transdermal patches of progesterone and investigate the release characterization in vitro .Methods SIS HMPSA was used as matrix material ,modified Franz diffu‐sion cell and excised female rat skin were used as model ,the concentration of progesterone was determined by HPLC .The thickness of patch and penetration enhancers was screened out by permeation rate .Results 2% IPM was used to prepare pro‐gesterone HMPSA transdermal patch ,thickness was 300 μm ,the cumulative permeation curve was Q=6 .172 1 t-5 .457 7 (r=0 .998 8) .The cumulative releases of the patches in 24 h was 144 .17 μg/cm2 . The permeation rate was (6 .17 ± 0 .49)μg/(cm2 · h) .Conclusion The progesterone HMPSA transdermal patch had good transdermal release in vitro ,which would have good clinical application prospect .