Inflammasome and diseases of central nervous system
10.3969/j.issn.1006-0111.2016.01.004
- VernacularTitle:炎症小体与中枢神经系统疾病
- Author:
Xiuming DU
1
;
Ziteng ZHANG
;
Ying ZONG
;
Chenlin YU
;
Xiaodong ZHANG
;
Guocai LU
Author Information
1. 第二军医大学卫生毒理学教研室
- Keywords:
inflammasome;
the central nervous system;
microglia;
macrophages;
Parkinson disease;
Alzheimer disease
- From:
Journal of Pharmaceutical Practice
2016;(1):12-15
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasome is the body of protein complex which is able to identify different stimulation signals and can in‐duce immune and inflammatory responses when it is activated .NLRP3 inflammasome has been extensively studied in the central nervous system .Microglia ,perivascular macrophages and meningeal macrophages express inflammasomes .The occurrence and development of acute brain infection ,aseptic acute brain injury ,Parkinson disease and Alzheimer disease are closely related to inflammasomes .Based on mechanisms exploration of the inflammasome′s role in the central nervous system disorders ,its tar‐get drug research and development will be greatly addressed in the future .
