Research progress in the synthesis of tumor-associated carbohydrate antigens (TACAs) GM3 and de rivatives
10.3969/j.issn.1006-0111.2016.01.002
- VernacularTitle:肿瘤相关糖抗原GM3及其衍生物合成方法研究进展
- Author:
Guojing BAI
1
;
Xiaojie BIAN
;
Kuo YAO
;
Junqi WU
;
Shichong YU
;
Qingguo MENG
;
Qiuye WU
Author Information
1. 烟台大学药学院
- Keywords:
GM3 and derivatives;
synthesis;
glycosyl donor;
glycosylacceptor;
glycosylation;
stereoselectivity
- From:
Journal of Pharmaceutical Practice
2016;(1):5-7,15
- CountryChina
- Language:Chinese
-
Abstract:
Glycosylation is the key step of the synthesis of GM3 ,its reaction conditions are very harsh ,the stereoselec‐tivities are usually poor ,and the configuration of anomeric carbon is difficult to control .Whetherαglycosidic bond can be con‐structed efficiently in sialylation reactions is an important criteria used to evaluate the reaction quality .Studies of GM3 and de‐rivatives methods generally relates to following areas :the choice of the donor compounds and receptor compounds ,the control of stereoselectivity ,and the development of some new glycosidic reaction catalyst .In recent years ,important progress has been made in this research area .Now ,we predominately make a summary and review on the progress of methods for the synthesis of GM3 and derivatives .
