Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism
10.3969/j.issn.1006-0111.2015.06.011
- VernacularTitle:盐酸哌甲酯速溶膜抗疲劳作用及其机制的研究
- Author:
Lihong ZHANG
1
;
Pinghua XU
;
Na WU
;
Chengying SHEN
;
Hailong YUAN
;
Jin HAN
Author Information
1. 江西中医药大学
- Keywords:
methylphenidate hydrochloride;
anti-fatigue;
load-weighted swimming test;
lactate dehydrogenase;
creatine kinase;
triglycerides
- From:
Journal of Pharmaceutical Practice
2015;(6):522-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films (MPH-OFDF) and its mechanism .Methods 60 mice were randomly divided into 6 groups as:normal control group (physiological sa-line) ,model group (physiological saline) ,Yiqiyangxue oral liquids positive group (7 .00 mg/kg) ,MPH-OFDF high-dose group (5 .20 mg/kg) ,MPH-OFDF middle-dose group (2 .60 mg/kg) and MPH-OFDF low-dose group (1 .30 mg/kg) .Besides the normal control group ,model group and positive group were orally administered ,the other groups are administered with the drug once daily sublingually daily for consecutive 15 days .The mice were put in the load-weighted swimming test 30 min after the last oral administration ,then the anti-fatigue effect was assessed based on recording exhausting swimming time and detec-ting the levels of serum lactale dehydrogenase (LDH) ,creatine kinase (CK) ,triglycerides (TG) in mice .Results Compared with control group ,the middle-dose and the high-dose MPH could prolong the exhausting swimming time (P<0 .05 ,P<0 .01) and decrease the activity of LDH and CK significantly (P<0 .05 ,P<0 .01);in addition the middle-dose MPH could decrease the content of TG (P<0 .05) .Conclusion The MPH had marked anti-fatigue effect that may be associated with reduced ser-um LDH ,CK and TG .
