Research progress in the synthesis of antigen Bacillus anthracis tetrasaccharide

VernacularTitle:炭疽杆菌表面四糖抗原全合成的研究进展
Author: Lei HUANG ¹ ; Kehan XU ; Junqi WU ; Kuo YAO ; Shichong YU ; Qiuye WU
Author Information

1. 第二军医大学药学院有机化学教研室
Keywords: anthrax tetrasaccharide; glycosylation; chemosynthesis
From: Journal of Pharmaceutical Practice 2015;(6):481-485,569
CountryChina
Language:Chinese
Abstract: Objective Anthrax is an anthropozoonosis caused by the bacterium Bacillus anthracis .Bacillus anthracis is an aerobic ,spore-forming ,rod-shaped bacterium ,which infects human through ingestion or inhalation of the spores .The exos-porium of spores of Bacillus anthracis contains tetrasaccharide antigen with specific chemical structure ,which can be used in preparation of glycoconjugates vaccines ,inducing an immune response .This paper reviewed articles in the last decade that re-ported research advances in chemical synthesis of anthrax tetrasaccharide ,presented the methods for synthesis ,and compared the advantages and limitations among different methods .