The correlation between the resistance rate of Acinetobacter baumannii and anti-microbial consumption
10.3969/j.issn.1006-0111.2015.05.024
- VernacularTitle:鲍曼不动杆菌耐药率与抗菌药物用量的相关性分析
- Author:
Jianjun WU
1
;
Yingfei BAO
;
Yang ZHAO
;
Heping CAI
;
Zhangwei YANG
;
Jia ZHOU
;
Xuebin WANG
;
Cuimin CHEN
Author Information
1. 西藏军区总医院药剂科
- Keywords:
A cinetobacter baumannii;
drug resistance;
consumption of antibacterial agents;
correlation
- From:
Journal of Pharmaceutical Practice
2015;(5):467-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relevance between the consumption of various antimicrobials and antimicrobial re-sistance of Acinetobacter baumanni in a grade three hospital during 2007 -2010 .Methods A retrospective analysis was per-formed to count and sort the defined daily doses (DDDs) and the consumption of various antimicrobials in the hospital between 2007 and 2010 .Meanwhile the resistance rates of Acinetobacter baumanni to different antimicrobials were collected in the same period .Data was analyzed by SAS 8 .2 statistical software package using Spearman correlation method .Results The resistance rate of Acinetobacter baumanni to imipenem was significantly positively correlated with the consumption of carbapenems (r=0 .954 6 ,P<0 .01) ,it is positively correlated with the dosage of imipenem (r=0 .849 2 ,P<0 .05) ,it is also significantly posi-tively correlated with the consumption of meropenem (r=0 .999 2 ,P<0 .05) ,and the consumption of amoxicillin/clavulanate potassium ,respectively(r=0 .800 5 ,P<0 .05) .There was no correlation between the resistance rate of Acinetobacter bauman-ni and the dosage of aminoglycosides ,fluoroquinolones ,even β-lactamase inhibitors(P>0 .05) .Conclusion The use of car-bapenems should be correlated with their indications strictly ,only applying to severe infection of Acinetobacter baumanni .The aminoglycosides of amikacin and β-lactamase inhibitors of cefoperazone/sulbactam are the better options to treat A cinetobacter baumanni infection .
