The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy ;in toxic adulterant detection of pharmaceutical excipient

VernacularTitle:药物辅料中有毒掺杂物的拉曼／近红外光谱法检测灵敏度评价
Author: Zhonghu ZHANG ¹ ; Hao LI ; Jun LI ; Feng LU
Author Information

1. 山东省食品药品检验研究院
Keywords: pharmaceutical excipient; Raman spectroscopy; near infrared (NIR) spectroscopy; sensitivity; moving win-dow correlation coefficient (MWCC) method
From: Journal of Pharmaceutical Practice 2015;(5):441-444
CountryChina
Language:Chinese
Abstract: Objective To develop a rapid method for the detection of toxic adulterant (diethylene glycol) in pharmaceuti-cal excipient (glycerol) .Method The detection sensitivity of Raman/near infrared (NIR) spectroscopy combined with moving window correlation coefficient (MWCC) method was evaluated .Results The detection sensitivity of Raman spectroscopy was superior to that of NIR spectroscopy and with the assistance of MWCC method ;the sensitivity had been further improved . Conclusion Raman spectroscopy has the potential to become the effective method in the on-site detection of toxic adulterant in pharmaceutical excipient .