Sepration and antitumor activities of secondary metabolites from marine actino-mycete Nocardiopsis sp .SCSIO 11492
10.3969/j.issn.1006-0111.2015.05.006
- VernacularTitle:海洋拟诺卡菌SCSIO 11492中次生代谢产物的分离及其抗肿瘤活性研究
- Author:
Ruiqiang SU
1
;
Yan LI
;
Kun PENG
;
Jie LI
;
Quan YANG
;
Xianwen YANG
Author Information
1. 广东药学院中药学院
- Keywords:
marine actinomycete;
Nocardiopsis sp .;
secondary metabolites;
anti-tumor
- From:
Journal of Pharmaceutical Practice
2015;(5):406-410
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore cytotoxic secondary metabolites from a marine actinomycete Nocardiopsis sp .SCSIO 11492 .Methods Isolation and purification were carried out by column chromatography over silica gel ,Sephadex LH-20 ,and ODS structures of the isolates were identified mainly by NMR spectroscopic data .And cytotoxic bioassay was performed using MTT method .Results Five compounds were identified as 2′-deoxyadenosine (1) ,2′-deoxythymidine (2) ,2′-deoxyuidine (3) ,uridine (4) ,1-O-palmitoyl-3-d-galactosyl-sn-glycerol spongilipid (5) .Compound 5 exhibited weak cytotoxic activity with IC50 value of 10 .9 μmol/L .Conclusion Five compounds were obtained from a marine actinomycete Nocardiopsis sp .SCSIO 11492 .All five compounds were reported for the first time from this genus .Compound 5 could be the bioactive compound re-sponsible for the cytotoxic activity of Nocardiopsis sp .SCSIO 11492 .
