Gut microbiota and inflammatory bowel disease
10.3969/j.issn.1006-0111.2015.05.001
- VernacularTitle:肠道微生态与炎症性肠病
- Author:
Lijuan HE
1
;
Jundong ZHANG
;
Maomao AN
;
Yuanying JIANG
Author Information
1. 第二军医大学药学院新药研究中心
- Keywords:
inflammatory bowel disease;
intestinal microbe;
interaction
- From:
Journal of Pharmaceutical Practice
2015;(5):385-388,422
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease is a chronic inflammation of the intestinal tract ,which comprises two primary forms of Crohn's disease(CD) and ulcerative colitis (UC) .Decades of studies have revealed that environmental factors ,suscepti-bility genes ,and gut microbiota are considered as the major determinants for the induction of IBD .The combination of factors has made IBD as an appropriate and a high-priority platform for studying host-microbiome interactions .More recently ,profiling studies of the intestinal microbe have associated pathogenesis of IBD with characteristic alterations in the composition of the in-testinal microbiota ,reinforcing the viewpoint that IBD results from the altered interplays between the host and intestinal mi-crobe .the studies of the gut flora in IBD were reviewed andthe multiple effects of intestinal microbiota-dysfunction on the IBD were described .The progress of intestinal microbiota alterations with different therapeutic methods in animal models and clinic trials were provided .
