Effect of litchi saponin and litchi flavones on insulin resistance in HepG 2 cells
10.3969/j.issn.1006-0111.2015.04.007
- VernacularTitle:荔枝核皂苷和荔枝核黄酮对He pG2细胞胰岛素抵抗作用研究
- Author:
Zhijun XIAO
1
;
Jiewen GUO
;
Feng XU
Author Information
1. 上海市奉贤区中心医院药剂科
- Keywords:
litchi saponin;
litchi flavones;
insulin resistance;
HepG2 cells
- From:
Journal of Pharmaceutical Practice
2015;(4):316-318,350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of litchi saponin and flavones on glycometabolism in insulin resistance model of HepG2 cells .Methods Using high insulin in HepG2 cells to establish a cell model of insulin resistance .Cell model was treated by litchi saponin ,litchi flavones and rosiglitazone ,respectively .Glucose concentration of cell culture supernatant was detected by glucose oxidase method .Results In the concentration of 10-6 mol/L insulin for 24 hours ,HepG2 reached the highest level of resistant to insulin ,which means a successful insulin resistance cell model was established .However ,no significant decrease in glucose concentration of cell culture supernatant was observed with litchi saponin and flavones .Conclusion This study sug-gests that litchi saponin and flavones have no effect to improve insulin resistance .
