Research progress of dual topoisomerase Ⅰ and Ⅱ inhibitors
10.3969/j.issn.1006-0111.2015.04.004
- VernacularTitle:拓扑异构酶Ⅰ和Ⅱ双重抑制剂的研究进展
- Author:
Yan JIANG
1
;
Chunquan SHENG
;
Guoqiang DONG
Author Information
1. 第二军医大学药学院药物化学教研室
- Keywords:
topoisomerase Ⅰ;
topoisomerase Ⅱ;
dual inhibitors;
anticancer drugs
- From:
Journal of Pharmaceutical Practice
2015;(4):303-308,379
- CountryChina
- Language:Chinese
-
Abstract:
DNA topoisomerases (Tops) are essential enzymes that regulate the cellular processes such as replication , transcription ,recombination and repair .DNA Tops can be classified into two types ,topoisomerase Ⅰ (TopⅠ ) and topoi-somerase Ⅱ (TopⅡ) .They catalyze the breakage and religation of DNA ,maintaining the topological changes of DNA and va-rious DNA metabolic processes .Due to their important role in DNA metabolism ,the ability to interfere with the functions of Tops or generating Top-mediated DNA damage is an effective strategy for cancer chemotherapy .Tops have been considered as the most important targets for tumor chemotherapy .In this review ,we used examples to describe the development of dual to-poisomerase Ⅰ and Ⅱ inhibitors .
