Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

VernacularTitle:文拉法辛缓释胶囊与西酞普兰片治疗脑卒中后抑郁患者的对照研究
Author: Shiyan XIA ¹ ; Zhuanghong SHEN ; Yingran ZHANG ; Peng ZHANG
Author Information

1. 萧山医院精神卫生中心
Keywords: post-stroke depression; venlafaxine; citalopram
From: Journal of Pharmaceutical Practice 2015;(2):173-175
CountryChina
Language:Chinese
Abstract: Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained‐release capsules and citalopram tablets in the treatment of post‐stroke depression .Methods 60 patients were randomly divided into venlafaxine group (n=30)and citalomram group(n=30) for 8 weeks treatment .Hamilton rating scale for depression(HAMD) and treat‐ment emergent system scale (TESS) were used to evaluate the efficacy and side effects ,respectively .Results After 4‐8 weeks of treatment ,both scores of HAMD of the two groups decreased significantly(P<0 .05) ,but there was no difference between the two groups(P>0 .05) .The total scores of HAMD in venlafaxine group were notably lower than citalopram group after 2 weeks(P<0 .05 ) .There was no significant difference in side effects between the two groups(P>0 .05) .Conclusion There was no significant difference in gross curative effect and side effects between two groups ;venlafaxine worked faster compared to citalopram .