Chemotherapeutic targeting of cancer-induced immunosuppressive cells:an update research
10.3969/j.issn.1006-0111.2015.02.019
- VernacularTitle:化疗药物靶向肿瘤相关免疫抑制性细胞的研究进展
- Author:
Qi JIANG
1
;
Qijun QIAN
Author Information
1. 东方肝胆外科医院肿瘤生物治疗科、病毒基因治疗实验室
- Keywords:
chemotherapeutics;
regulatory T cell;
myeloid-derived suppressor cell;
chemoimmunotherapy;
cancer-in-duced immunosuppressive cell
- From:
Journal of Pharmaceutical Practice
2015;(2):163-166,182
- CountryChina
- Language:Chinese
-
Abstract:
Cancer‐induced immunosuppressive cells play an important immunosuppressive role during the tumor develop‐ment process ,and the development and progression of tumors are always accompanied with abnormal accumulation of cancer‐in‐duced immunosuppressive cells .Regulatory T lymphocytes (Treg) and myeloid‐derived suppressor cells (MDSC) are major components of these inhibitory cellular networks ,and they can inhibit antitumor immune response through multiple mecha‐nisms .Recent studies have provided evidence that beyond their direct cytotoxic or cytostatic effects on cancer cells ,some con‐ventional chemotherapeutic drugs and agents used in targeted therapies can promote the elimination or inactivation of suppres‐sive Tregs or MDSCs ,resulting in enhanced anti‐tumor immunity .Hence ,chemotherapeutics ,used as a preconditioning regi‐men and combined with subsequent immunotherapy ,can promote anti‐tumor immune response .Anticancer chemoimmunothera‐py strategy will change the recognization of the role for conventional chemotherapy in anticancer treatment ,and it will be help‐ful to optimize the chemotherapy strategies more reasonably .
