Optimization of synthesis of photosensitizer chlorin e6-C15 monomethyl ester by the orthogonal design
10.3969/j.issn.1006-0111.2015.02.007
- VernacularTitle:正交设计优化光敏剂二氢卟吩e6-C15单甲酯的合成工艺
- Author:
Bin SHAN
1
;
Miao SUN
;
Zhi MENG
;
Guiyan HAN
;
Qihan QIAN
;
Minghui LIU
;
Jianzhong YAO
Author Information
1. 福建中医药大学药学院
- Keywords:
process improvement;
chlorine e6-C15 monomethyl ester;
orthogonal design;
photosensitizer
- From:
Journal of Pharmaceutical Practice
2015;(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the synthesis of photosensitizer chlorine e6‐C15 monomethyl ester (1) .Methods Tar‐get compound 1 was synthesized through E ring cracking of pheophorbide a (3) in methanol solution of potassium hydroxide followed by adding H2 O for ester hydrolysis with“one‐pot” process .Four main factors that influencing the synthetic yield of target compound 1 are ring cleavage reaction time (A) ,reflux hydrolysis reaction time (B) ,alkali concentration (C) and weight ratio of material 3 to alkali (D) .Each of the four factors was chosen at three levels and evaluated by the orthogonal ex‐perimentaldesignofL9(34).Results Theoptimizationtermsofthesynthesisoftargetcompound1wereB1C2A2D1 .Theyield of compound 1 was raised from 43 .0% to 56 .5% .Conclusion The developed process has the advantages of simple operation , good safety and high reaction yield ,and is suitable for industrial production .
