Oxidized meosporous carbon nanospheres as carriers for paclitaxel
10.3969/j.issn.1006-0111.2015.02.005
- VernacularTitle:氧化介孔碳球纳米粒作为紫杉醇载体的研究
- Author:
Huan WANG
1
;
Lan SHE
;
Linzhao WANG
;
Zhiqiang MA
;
Xinrong ZHANG
;
Feng YANG
Author Information
1. 福建中医药大学药学院
- Keywords:
mesoporous carbon;
nanoparticles;
surface modification;
tumour;
drug delivery system
- From:
Journal of Pharmaceutical Practice
2015;(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel .Methods Physicochemical properties such as morphology ,diameter ,pore diameter and pore volume were characterized .Drug‐loading capacity was measured and drug release behavior in vitro was investigated by dialysis method .In vitro antitumour effect was evaluated by CCK‐8 methods .Results The synthesized oxidized mesoporous carbon nanospheres had an average diameter of 140 nm ,Zeta potential of -36 mV ,high specific surface area of 704.63 m2/g ,high drug‐loading capacity of 45 .6% .Conclusion Oxidized mesoporous carbon nanospheres have promising application in anti‐cancer drug delivery system .
