Stability of sodium nitroprusside for injection in two different dissolvants
10.3969/j.issn.1006-0111.2015.01.017
- VernacularTitle:注射用硝普钠在2种溶媒中的稳定性考察
- Author:
Xiaoming LIN
1
;
Baohan WEI
;
Yi ZENG
;
Pingyuan WEI
;
Hanqin LIANG
;
Weiqian XIE
;
Mingzhong CHEN
Author Information
1. 广西贵港市人民医院
- Keywords:
sodium nitroprusside;
HPLC;
combination;
stability
- From:
Journal of Pharmaceutical Practice
2015;(1):63-64,93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the stability of sodium nitroprusside for injection in 5% glucose injection and 0 .9%sodium chloride injection ,and provide reference for clinical rational drug use .Methods The content of sodium nitroprusside for injection in different dissolvants(5% glueose ,sodium chloride injection) within 26 h was determined by HPLC .The change of micro particle was measured by light blockage method in accordance with China pharmacopeia(2010 edition) ,and the appearance and UV visible absorption spectroscopy and pH ,the osmotic pressure of the mixtures were observed as well .Results The changes in appearnace ,UV visible absorption spectroscopy ,pH value ,content and microparticle were not significant .Conclusion Sodium nitroprusside for injection were stable within 26 h after mixing with different dissolvants (5% glueose ,sodium chloride injection) .
