Preparation and characterization of salinomycin sodium loaded nano liposomes

VernacularTitle:盐霉素钠纳米脂质体的制备及表征
Author: Zhirong GONG ¹ ; Wenting HE ; Zhiguo SUN ; Haixia GUO ; Yanqiang ZHONG ; Ying LU
Author Information

1. 第二军医大学药学院
Keywords: cancer stem cells; salinomycin sodium; liposomes; entrapment efficiency; optimization of preparation
From: Journal of Pharmaceutical Practice 2015;(1):36-39,43
CountryChina
Language:Chinese
Abstract: Objective To prepare and characterize salinomycin sodium‐loaded nano liposomes(SLN) .Methods The nano liposomes were prepared by a thin‐film dispersion method .The formula of SLN was optimized by regulating the cholesterol ratio of the nano liposomes ,using the encapsulation efficacy (EE) of SLN as the primary outcome measure .Results Transmission e‐lectron microscope (TEM) showed that SLN was round and had a good dispersion .Dynamic laser scatter (DLS) showed that SLN was of a desired size of 99 nm ,and zeta potential of -33 .5 mV .EE of SLN was 85 .7% and drug loading of 6 .7% .Ac‐cording to the formulation of nano liposomes ,the concentration of salinomycin sodium in water was greatly improved by 15 folds .Additionally ,the nano liposomes were observed to exhibit sustained release characteristics .Conclusion Salinomycin sodi‐um‐loaded nanoliposomes of a desired size of about 100 nm were obtained ,which were well dispersion ,and high EE and drug loading .Solid pharmaceutics foundation for the activity examination of SLN was provided in this research .