Research progress of bioactive peptide monocyte locomotion inhibitory factor
10.3969/j.issn.1006-0111.2015.01.005
- VernacularTitle:生物活性肽-单核细胞迁移抑制因子研究进展
- Author:
Hao CHENG
1
;
Yaocheng RUI
;
Yuefan ZHANG
;
Tiejun LI
Author Information
1. 安徽中医药大学药学院
- Keywords:
monocyte locomotion inhibitory factor;
inflammation;
immune;
bioactive peptide
- From:
Journal of Pharmaceutical Practice
2015;(1):17-19,27
- CountryChina
- Language:Chinese
-
Abstract:
Monocyte locomotion inhibitory factor(MLIF)was an anti‐inflammatory pentapeptide produced by Entamoeba histolytica .In vivo and in vitro study showed that MLIF displayed anti‐inflammatory and immune protection effects and MLIF had protective effects on rheumatoid arthritis ,nerve injury ,myocardial ischemia ,cerebral ischemia and Alzheimer′s disease . Studies had shown that MLIF regulated inflammatory response and immune protection through NF‐κB and MAPK signal path‐ways .The sources and biological activities of MLIF were reviewed in this paper .
