Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumo rs
10.3969/j.issn.1006-0111.2015.01.003
- VernacularTitle:双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用
- Author:
Hongyuan GAO
1
;
Jianyong WU
;
Shumin NI
Author Information
1. 复旦大学附属华山医院静安分院 肿瘤科
- Keywords:
dual-targeting;
nano-carrier;
brain tumor;
diagnosis;
therapy
- From:
Journal of Pharmaceutical Practice
2015;(1):9-12,16
- CountryChina
- Language:Chinese
-
Abstract:
The delivery of therapeutical agents for brain tumors′ treatment is enormously prevented by the presence of blood‐brain barrier .Nano‐carriers such as nano‐particles ,liposomes and micelles can significantly increase the transport of drugs across the blood‐brain barrier .The dual‐targeting nano‐carriers modified by one or two functional groups can further increase the brain delivery of drugs as well as their accumulation in brain tumors ,resulting in significant improvement in the diagnosis and therapy of brain tumors .This article mainly focused on the recent development of strategies and functional groups of dual‐targeting nano‐carriers ,providing a reference for relevant investigations .
