Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins in-clusion compound
10.3969/j.issn.1006-0111.2014.06.014
- VernacularTitle:白杨素-羟丙基-β-环糊精包合物的制备与表征
- Author:
Qian ZENG
1
;
Hui JI
;
Huihui TANG
;
Xueyuan XIE
Author Information
1. 海军总医院药剂科
- Keywords:
chrysin;
hydroxypropyl-β-cyclodextrins;
preparation;
characterization
- From:
Journal of Pharmaceutical Practice
2014;(6):456-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin .Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins in-clusion compound .The PXRD, DSC and IR techniques had been used to characterize the inclusion compound .Results Chrysin and hydroxypropyl-β-cyclodextrins had formed the inclusion compound , and the formation of the inclusion compound could increase solubili-ty by 120.7 times.Conclusion The inclusion compound preparation method was simple and available , which was suitable to improve the bioavailability .
