Effects and mechanism of TG6 on myocardial ischemia and reperfusion injury
10.3969/j.issn.1006-0111.2014.06.010
- VernacularTitle:新化合物TG6对心肌缺血／再灌注损伤的影响及机制研究
- Author:
Jingjing CHENG
1
;
Mouzhi LIU
;
Hongjiao LI
;
Lan YAN
;
Yuanying JIANG
;
Tianhua YAN
Author Information
1. 武警河南省总队医院药剂科
- Keywords:
NHEI;
myocardial ischemia/reperfusion;
coronary artery ligation;
isolated heart perfusion;
cardiomyocyte;
H/R
- From:
Journal of Pharmaceutical Practice
2014;(6):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects and mechanism of TG 6 on myocardial ischemia/reperfusion injury . Methods the protective effects of TG 6 on myocardial ischemia/reperfusion was investigated by setting up models of ischemia and reperfusion of rats induced by ligating the left coronary anterior descending artery in vivo,isolated rat hearts through an improved Lange-ndorff device, and hypoxia /reoxygenation injury of neonatal rat cardiomyocytes , and the serum CK,LDH,T-SOD, MDA were taken as research markers .Results TG6 significantly reduced the myocardial infarct size , decreased the activity of CK and the content of MDA in serum, reduced the activity of LDH, and increased the activity of T-SOD in vivo;TG6 obviously increased the coronary blood flow after low rate perfusion and reperfusion , decreased the content of MDA and the leakage of CK , LDH in myocardial tissue , elevated the activity of T-SOD in vitro of isolated rat hearts;TG6 had no effects on cells in normal growth condition , raised the viability of cardio-myocytes significantly, and reduced the rate of CK leakage and the content of [Ca2+]i obviously in Na2S2O4 treated cells in vitro of neonatal rat cardiomyocytes .Conclusion TG6 could effectively protect myocardial ischemia/reperfusion injury .
