Screening of potential active anti-cancer components of Brucea javanica by SMMC-7721 and Hep-G2 comprehensive two dimensional CMC-monolith chro-matography
10.3969/j.issn.1006-0111.2014.06.007
- VernacularTitle:用SMMC-7721和Hep-G2全二维细胞膜-整体柱色谱联用技术筛选中药鸦胆子的抗癌活性物质
- Author:
Songgang JI
1
;
Xuan DING
;
Yan CAO
;
Xiaofei CHEN
;
Dan JIA
;
Dongyao WANG
;
Yifeng CHAI
Author Information
1. 解放军401医院药剂科
- Keywords:
cell membrane chromatography;
comprehensive two dimensional chromatography;
SMMC-7721;
Hep-G2;
Bru-cea javanica;
anti-cancer
- From:
Journal of Pharmaceutical Practice
2014;(6):425-427,433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen potential active anti-cancer components of Brucea javanica.Methods This research has em-ployed comprehensive two dimensional chromatographic technology and cell membrane chromatographic technology simultaneously with mass spectrometry as detector .Results Adenosine and Bruceine B were found to be potentially anti-cancer active .Conclusion This study has combined the advantages of online , high speed and high throughput for the screen of potential active components of traditional Chinese medicine .
