Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies
10.3969/j.issn.1006-0111.2014.06.004
- VernacularTitle:降脂药物的肝脏毒性及其防治策略研究进展
- Author:
Yancheng XU
1
;
Yijie FANG
;
Lan YAN
;
Yuanying JIANG
;
Yongbing CAO
Author Information
1. 福建中医药大学药学院
- Keywords:
hyperlipidemia;
drug;
hepatotoxicity
- From:
Journal of Pharmaceutical Practice
2014;(6):412-415,464
- CountryChina
- Language:Chinese
-
Abstract:
Hepatotoxicity is one of the most common adverse reactions during anti -hyperlipidemia treatment .Mechanisms of anti-hyperlipidemia drug-induced hepatotoxicity are not clear yet , but most of the toxic reactions are dose-related hypersensitivity and could be released after drug withdrawal .It is accepted that clinical risk factors for the development of hepatotoxicity during anti -hyper-lipidemia treatment are high age and chronic illnesses .Treatment of anti-hyperlipidemia drug-induced hepatotoxicity has not been uni-fied and most of the treatments are non-specific and symptomatic .Researching hypotoxicity and hepatoprotection antihyperlipidemia drug, especially TCM and pharmaceutics will become a promising direction .
