Stability of tramadol hydrochloride with fentanyl citrate in 0 .9%sodium chloride injection

VernacularTitle:盐酸曲马多与枸橼酸芬太尼在氯化钠注射液中的稳定性研究
Author: Baoxia FANG ¹ ; Fuchao CHEN ; Chunlei LI ; Huimin LIU ; Xuesong ZHU
Author Information

1. 湖北医药学院附属东风医院药学部
Keywords: tramadol; fentanyl; compatibility stability; HPLC
From: Journal of Pharmaceutical Practice 2014;(5):348-351
CountryChina
Language:Chinese
Abstract: Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9%sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9%sodium chloride injection within 72 hours at ambient temperature were observed .The concentrations of the two drugs were determined by HPLC .The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min..Results No significant differences were found in the pH value and appearance of the solution . The contents of tramadol hydrochloride and fentanyl citrate were high than 98%within 72 hours.Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9%sodium chloride injection was stability within 72 hours under room temperature .