Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicilli-um canescens
10.3969/j.issn.1006-0111.2014.05.006
- VernacularTitle:青霉属生物中分离出的抗真菌四肽的固相合成
- Author:
Lujing YANG
1
;
Lu WANG
;
Wenjuan LI
;
Renwu LI
;
Xiaoyan WANG
;
Honggang HU
Author Information
1. 第二军医大学 研究生管理大队
- Keywords:
antifungal;
tetrapeptide;
solid-phase synthesis
- From:
Journal of Pharmaceutical Practice
2014;(5):342-343,378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method .Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1 H NMR.Results The synthesis of the D-Phe-Val-D-Val-Tyr-OH was realized with yield of 47%.Conclusion The synthetic method was feasible and practical.The desired target tetrapeptide could be used for screening of antifungal activity .
