Study on receptor gene polymorphism and detection method of vitamin D
10.3969/j.issn.1006-0111.2014.05.003
- VernacularTitle:维生素D受体基因的多态性与检测方法
- Author:
Chunhua YOU
1
;
Xiaojuan XIONG
;
Qinghua WANG
;
Wansheng CHEN
;
Shouhong GAO
Author Information
1. 第二军医大学附属长征医院药学部
- Keywords:
vitamin D;
gene polymorphism;
vitamin D receptor;
rational drug use
- From:
Journal of Pharmaceutical Practice
2014;(5):329-331,392
- CountryChina
- Language:Chinese
-
Abstract:
In recent years , many studies have found that vitamin D insufficiency is associated with osteomalacia , hyperten-sion, diabetes, metabolic syndrome and other diseases .Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1,25-dihydroxy vitamin D ,which binds to the intracellular vitamin D receptor and exerts its effects .This paper reviewed the relationship between vitamin D and disease , present research situation of gene polymorphism of vitamin D receptor , and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally .
