To improve the preparation process of pericardial fixation fluid and study its sta-bility
10.3969/j.issn.1006-0111.2014.04.013
- VernacularTitle:心包固定液的制备工艺改进及稳定性考察
- Author:
Xin SUN
1
;
Yuanyuan GU
;
Xueping YANG
;
Wei LIU
Author Information
1. 解放军88医院药剂科
- Keywords:
pericardial fixation fluid;
preparation technology;
solution stability
- From:
Journal of Pharmaceutical Practice
2014;(4):288-289,296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a population pharmacokinetic ( PPK) model of metformin in healthy Chinese subjects , and evaluate the effect of different physiological factors on pharmacokinetic parameters of metformin .Methods The preparation of pericar-dial fixation liquid is divided into solution A ( buffer solution ) and solution B ( glutaraldehyde solution ) , which were reserved in the re-frigerator before used .Before the experiment , solution A and B were mixed evenly to make fresh pericardial fixation fluid .Stability of solution A and B before and after disinfection , solution B, pericardial fixation fluid at room temperature and 4℃in the refrigerator were studied using pH meter and hydroxylamine salt method with pH value and the content as indexes .Results The decline of pH value and the content was slight after disinfection for both solution A and B within the prescribed scope .when glutaraldehyde was in alkaline con-dition after the mix of solution A and B , it was with strong bactericidal activity and pericardial fixation ability;stability study showed that pericardial fixation fluid was more stable in cold storage than at room temperature within one year .Conclusion The improved preparation process of pericardial fixation fluid is reasonable and feasible .The pericardial fixation fluid has good stability , and the quality guarantee period could be extended to one year .
