Clinic research on Saccharomyces boulardii in preventing and treating antibiotics associated diarrhea in infant pneumonia
10.3969/j.issn.1006-0111.2014.03.016
- VernacularTitle:布拉酵母菌防治婴幼儿肺炎继发抗生素相关腹泻的临床研究
- Author:
Jiming LI
1
;
Huifen ZHANG
;
Hui XIE
;
Tong SHEN
Author Information
1. 厦门市妇幼保健院
- Keywords:
infant pneumonia;
antibiotic associated diarrhea;
Saccharomyces boulardii
- From:
Journal of Pharmaceutical Practice
2014;(3):222-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of Saccharomyces boulardii on antibiotics associated diarrhea (AAD)in infant pneumonia.Methods 302 hospitalized infant patients (1 month-3 years) with pneumonia but without gastroenteric disease were selected , and antibiotics were administrated intravenously at least 5 continuous days for each patient .Patients were all giv-en antibiotics and randomly divided into three groups:control group with no Saccharomyces boulardii administration ( group A, 60 ca-ses);Saccharomyces boulardii were applied as addition on the occurrence of diarrhea (group B, 92 cases), and Saccharomyces boular-dii and antibiotics were co-administrated (group C, 150 cases).Incidences of AAD in all groups were carefully examined and differ-ences of therapeutic effect between groups were compared and analyzed .Results The incidence of AAD in Group C was significantly lower than that in other groups .In term of diarrhea severity, no significant difference was observed in all groups (P>0.05).Howev-er, duration of diarrhea showed significant different between groups (P<0.001):group A with the longest duration and group C with the shortest .The results indicated that the total efficiency of anti-diarrhea in group C was significantly higher than that in control group (P<0.05).However, group B presented no significant difference compared with neither control group nor group C in term of therapeu -tic effect on diarrhea .Conclusion Administration of Saccharomyces boulardii Sachets could shorten the duration of diarrhea on the oc-currence of AAD in infant pneumonia .According to our results , Saccharomyces boulardii was effective in both preventing the develop-ment of AAD and shortening duration of diarrhea , and therefore improved therapeutic effect on ADD .
