Screening the best ratio of artesunate and ursolic acid for lipid-lowering
10.3969/j.issn.1006-0111.2014.03.008
- VernacularTitle:青蒿琥酯和熊果酸降血脂作用的最佳配比筛选
- Author:
Yalin YE
1
;
Yuliang WANG
;
Zejian WANG
;
Ming YIN
;
Hailiang XIN
;
Lei ZHANG
Author Information
1. 解放军421医院药剂科
- Keywords:
artesunate;
ursolic acid;
hyperlipidemia;
rat;
lipid metabolism
- From:
Journal of Pharmaceutical Practice
2014;(3):195-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats′model, find out the best ratio of artesunate and ursolic acid .Methods Lipid metabolism disorders model was in-duced by feeding high fat diet in rat .The best ratio was screened through comparing the lipid level of rats ofdifferent groups .Results The results showed that Artesunate ( high dose ) +Ursolicacid ( high dose ) significantly reduced TG , CHO and LDL-C, increased HDL-C and H/L.Lipid-lowering effect was superior the positive drug fenofibrate , but also superior to the same dose of artesunate and ursolic acid alone.No significant effect of each test sample on the rat liver function was observed (P>0.05).Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.
