Synthesis and antifungal activities of novel triazole derivatives
10.3969/j.issn.1006-0111.2014.03.006
- VernacularTitle:新型三唑类衍生物的合成及其抗真菌活性研究
- Author:
Maocheng WU
1
;
Xiang LI
;
Qiuye WU
Author Information
1. 第二军医大学药学院有机化学教研室
- Keywords:
triazole derivatives;
chemical synthesis;
antifungal activity
- From:
Journal of Pharmaceutical Practice
2014;(3):186-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize a new series of triazole compounds with naphthalene benzyl as side chain and evaluate the antifungal activity .Methods Nine title compounds were synthesized and determined by the 1 H NMR and MS spectra .According to the method recommended by the national committee for clinical laboratory standards (NCCLS), the RPMI-1640 test medium was used, the antifungal activities of all the compounds were evaluated against eight human pathogenic fungi in vitro.Results The title com-pounds exhibited potent antifungal activities .Compound 1c showed high activities against 7 funguses except Aspergillus fumigatus with the MIC80 values less than 0.125μg/ml, which was 16 times higher than that of Voriconazole .Conclusion The title compounds with naphthalene and alkyl substituent showed potent antifungal activities .
