Progress in pathophysiology and related drug development of hypoxia-inducible factor-1
10.3969/j.issn.1006-0111.2014.03.001
- VernacularTitle:低氧诱导因子-1的病理生理及相关药物研究进展
- Author:
Shijie FENG
1
;
Xiujuan MA
;
Ying ZONG
;
Yu MAO
;
Xiaodong ZHANG
;
Xuelian GONG
;
Xiaofang ZHANG
;
Guocai LU
Author Information
1. 第二军医大学卫生毒理学教研室
- Keywords:
hypoxia-inducible factor-1;
hypoxia-response element;
oxygen homeostasis;
activity regulation;
inhibitor
- From:
Journal of Pharmaceutical Practice
2014;(3):161-166
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1 (HIF-1) is a critical nuclear transcriptional factor mediating cell adaptive response to hypoxia in mammalian and human .It is the key mediator which modulates oxygen homeostasis exclusively .In the one hand , HIF-1 can protect and promote kinds of physiological processes , such as embryo normal development , cartilage and bone formation .In the other hand, it is also involved in lots of human deceases which is caused by ischemia and hypoxia , such as tumor, diabetes and its complica-tions.The molecular mechanisms of HIF-1 involved in these diseases have become a research hotspot and such studies will provide the new therapeutic means for these diseases , recent new drug researches have been focused on HIF-1 related signal pathway inhibitors , HIF-1 activity inhibitors, HIF-1 targeted therapy, etc.
