Studies on quality control of dexamethasone liposomes
10.3969/j.issn.1006-0111.2001.02.011
- VernacularTitle:地塞米松脂质体质量控制方面的研究
- Author:
Yong-Hong ZHENG
1
;
Dong-Qin QUAN
Author Information
1. 国家生物医学分析中心
- Keywords:
dexamethasone;
liposome;
k-ratio spectrophotometry;
entrapment efficiency
- From:
Journal of Pharmaceutical Practice
2001;19(2):86-88
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the main aspects of quality control of dexamethasone liposomes.METHODS:The structure of liposomes was studied with negative staining method of TEM.K-ratio spectrophotometry was wsed to determine the contert,and the Macrosep was wsed to seperate the entrapped from free drugs.RESULTS:An excellent linear relationship was obtained with the range of 4~52μg/ml,the average recovery percent was between 98.28%~99.71%.The entrapment efficiency was one of the important parameters of liposomes quality control.It was related with the clinical effect directly,the entrapment efficiency was more than 80%.CONCLUSION:This method is accurate,quick and reproducible.