Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat
10.3969/j.issn.1006-0111.2001.02.007
- VernacularTitle:四氯化碳致大鼠肝纤维化模型血液流变学性质的研究
- Author:
Wan-Guo ZHANG
1
;
Jin-Hong HU
;
Zhen CAI
Author Information
1. 第二军医大学附属长海医院
- Keywords:
hepatic fibosis;
hemorheology;
red blood cell;
carbon tetrachloride
- From:
Journal of Pharmaceutical Practice
2001;19(2):78-79
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS:Hepatic fibrosis in rat was induced by CCl4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS:As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION:High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.
