Influence of different dose of atorvastatin on blood pressure ,blood lipids and vascular endothelial func‐tion in hypertensive patients with hyperlipidemia
10.3969/j.issn.1008－0074.2019.05.15
- VernacularTitle:不同剂量阿托伐他汀对高血压合并高脂血症患者血压、血脂及血管内皮功能的影响
- Author:
Ping QI
1
;
Zhi-Guo YIN
Author Information
1. 安康市中心医院药学部
- Keywords:
Hypertension;
Hyperlipidemias;
Dose‐response relationship,drug;
Atorvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(5):619-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore influence of different dose of atorvastatin on blood pressure ,blood lipids and vascular en‐dothelial function in hypertensive patients with hyperlipidemia .Methods :A total of 100 hypertensive patients with hyper‐lipidemia treated in our department of cardiology from Jan to Oct 2017 were randomly and equally divided into atorvastatin low dose group (atorvastatin 10mg／d) and high dose group (atorvastatin 20mg／d) ,both groups simultaneously received rou‐tine treatment for eight weeks .Another 50 healthy volunteers undergoing physical examination in our hospital were selected as healthy control group .Levels of blood pressure ,von Willebrand factor (vWF) etc.were measured and compared among three groups .Results :Compared with low dose group after eight‐week treatment ,there were significant reductions in levels of SBP [(147.33 ± 11.37) mmHg vs.(140.51 ± 10.85) mmHg] ,DBP [(96.35 ± 7.38) mmHg vs.(92.56 ± 6.83) mm‐Hg] ,TG [ (2.38 ± 0.59) mmol／L vs.(1.55 ± 0.46) mmol／L] ,TC [ (6.48 ± 0.58) mmol／L vs.(5.38 ± 0.52) mmol／L] ,LDL‐C [ (4.24 ± 0.41) mmol ／L vs.(3.26 ± 0.42) mmol／L] ,hsCRP [ (6.38 ± 1.53) mg／L vs.(5.05 ± 1.38) mg／L] , ET‐1 [ (80.78 ± 18.54) pg／ml比(73.22 ± 10.98) pg／ml] and significant rise in HDL‐C level [ (1.13 ± 0.27) mmol／L vs.(1.29 ± 0.25) mmol／L] in high dose group , P＜0.05 or ＜0.01. Conclusion :Different doses of atorvastatin possesses different therapeutic effect on hypertensive patients with hyperlipidemia .Therapeutic effects lowering blood pres‐sure and blood lipids ,improving vascular endothelial function and reducing levels of inflammatory factors of 20mg atorvas‐tatin is significantly better than those of 10mg atorvastatin ,which is worth extending.
