Changes of plasma BNP and copeptin levels in patients with CHF of different degrees and their correla‐tion with cardiac function class
10.3969/j.issn.1008－0074.2019.05.06
- VernacularTitle:不同程度CHF患者血浆 BNP、和肽素水平变化及其与心功能分级的相关性
- Author:
Yan SHEN
1
;
Rui-Min GAO
;
Ling-Ling KANG
;
Jian-Feng XU
;
Hua YUE
;
Shou-Jun ZHANG
Author Information
1. 唐山市工人医院分院心内科
- Keywords:
Heart failure;
Natriuretic peptide,brain;
Ventricular function
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(5):583-586
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore changes of plasma levels of BNP and copeptin (CPT) in patients with chronic heart failure (CHF) of different degrees and their correlation with cardiac function class .Methods :A total of 150 CHF patients treated in our hospital from Feb 2015 to Feb 2017 ,were selected as CHF group .Another 45 healthy volun‐ teers undergoing physical examination in our hospital simultaneously were regarded as healthy control group .Plasma BNP and CPT levels were compared between two groups .According to NYHA cardiac function class ,CHF group was further divided into class II group (n＝48) ,class III group (n＝51) and class IV group (n＝51).Plasma levels of BNP and CPT etc .were measured and compared among three subgroups .Correlation among BNP ,CPT levels and cardiac function class were analyzed in CHF patients .Results :Compared with healthy control group ,there were significant rise in plasma levels of BNP and CPT in CHF group , P＝ 0.001 both .Compared with class II group , there were significant rise in plasma levels of BNP [ (1002.82 ± 101.33) pmol／L vs.(1515.05 ± 166.73) pmol／L vs.(2102.36 ± 227.32) pmol／L] ,CPT [ (6.51 ± 1.01 ) pmol／L vs.(9.28 ± 2.89 ) pmol／L vs .(14.03 ± 3.72 ) pmol／L] and LVEDd [ (51.51 ± 4. 01) mm vs.(59.28 ± 6.19) mm vs.(64. 03 ± 5.72) mm] ,and significant reduc‐tion in LVEF [ (50. 82 ± 6. 33)% vs.(45.05 ± 4.73)% vs.(41.36 ± 2.32)%] in class III group and class IV group , and plasma levels of BNP ,CPT ,LVEDd in class IV group were significantly higher than those of class III group , and LVEF was significantly lower than that of class III group , P＝0. 001 all.Spearman correlation analysis indicated that plasma levels of BNP and CPT were significant positively correlated with cardiac function class in CHF patients ( r＝0.320 ,0.302 , P＝0.009 ,0.011).Conclusion :Along with CHF aggravates ,the plasma levels of BNP and CPT significantly rise .Cardiac function class is significant positively correlated with plasma levels of BNP and CPT .
