Preliminary study on the relationship between histogram analysis of DCEGMRI quantitative parameters and clinical stage of nasopharyngeal carcinoma
10.3969/j.issn.1002-1671.2019.10.009
- VernacularTitle:动态对比增强磁共振成像定量参数直方图分析与鼻咽癌临床分期的相关性初步研究
- Author:
Xin GAO
1
;
Lijuan ZHOU
;
Xiaoqiu XU
;
Xiaohong SHEN
;
Li ZOU
;
Jiangfen WU
;
Junkang SHEN
Author Information
1. 苏州市独墅湖医院放射科
- Keywords:
nasopharyngeal carcinoma;
dynamic contrast-enhanced magnetic resonance imaging;
histogram analysis;
stage
- From:
Journal of Practical Radiology
2019;35(10):1590-1594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between histogram analysis of DCE-MRI quantitative parameters and clinical stage of nasopharyngeal carcinoma (NPC).Methods 70 patients with NPC confirmed by pathology underwent MRI examination and staging.NPC tumors were measured by full-volume ROI setting method,and the obtained DCE-MRI quantitative parameters were analyzed by histogram.Spearman correlation coefficients were obtained to evaluate the potential correlation between the DCE-MRI histogram quantitative parameters and NPC clinical stages.Results The histogram-based Ktrans (mean,10 th,75 th,90 th),Kep (mean,10 th,kurtosis),and Ve (mean,90 th,skewness)had correlation with T stage (P＜0.05,respectively).The histogram-based Ktrans (mean)and Ve (mean,90 th) showed correlation with N stage (P＜0.05,respectively).The histogram-based Kep (kurtosis)and Ve (mean)had correlation with M stage (P＜0.05,respectively).The histogram-based Kep had no correlation with N stage,and Ktrans had no correlation with M stage. The histogram-based Ktrans (mean,10 th,75 th,90 th),Kep (10 th,75 th,kurtosis)and Ve (mean,75 th,90 th)had correlation with overall stage (P＜0.05,respectively).Conclusion The histogram analysis of DCE-MRI quantitative parameters showed that the multiple parameters associated with NPC overall stages.DCE-MRI quantitative parameters non-invasively reflect the aggressiveness and progression of NPC.The histogram analysis of DCE-MRI quantitative parameters may play a role in clinical stage of NPC.
