International normalized ratio as a predictor of mortality in trauma patients in India
10.5847/wjem.j.issn.1920-8642.2014.03.006
- Author:
Verma ANKUR
1
;
Kole TAMORISH
Author Information
1. Department of Emergency Medicine
- Keywords:
Hemorrhage;
Trauma;
International normalized ratio;
Mortality
- From:
World Journal of Emergency Medicine
2014;5(3):192-195
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Hemorrhage is the second leading cause of death in trauma patients preceded only by traumatic brain injury. But hemorrhagic shock is the most common cause of preventable death within 6 hours of admission. Traumatic coagulopathy is a hypocoagulable state that occurs in the most severely injured. International normalized ratio (INR) and its relationship with trauma mortality have not been studied specifically. This study aimed to establish a predictive value of INR for trauma-related mortality. METHODS: A total of 99 trauma patients aged 18–70 years were included in the study. Their INR was determined and patient progression was followed up till death/discharge. According to previous retrospective studies, the cutoff value for INR in our study was kept at 1.5. RESULTS: The total mortality rate of the patients was 16.16% (16/99). The mean INR was 1.45 with a SD of 1.35. INR was deranged in a total of 14 patients (14.14%). Of these patients, 11 died (78.57%) and 3 survived. INR was deranged in 11 (68.75%) of the 16 patients who died, but 5 deaths (31.25%) had normal INR values. The sensitivity of INR was 69% (95%CI 41%–88%) and the specificity 96% (95%CI 90%–99%). The diagnostic accuracy of INR was 92% (95%CI 85%–96%). Positive predictive value and negative predictive value were 79% (95%CI 49%–95%) and 94% (95%CI 87%–98%), respectively. CONCLUSION: Our results showed that INR is a good predictor of mortality in trauma patients.