Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times
10.5847/wjem.j.issn.1920-8642.2013.03.009
- Author:
Ming LIU
1
;
Hai-Rong WANG
;
Jia-Fu LIU
;
Hao-Jun LI
;
Shen-Xing CHEN
;
Sha SHEN
;
Shu-Ming PAN
Author Information
1. Department of Emergency Medicine
- Keywords:
Acute cerebral infarction;
Thrombolysis;
Recombinant tissue type plasminogen activator
- From:
World Journal of Emergency Medicine
2013;4(3):205-209
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.METHODS:A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.RESULTS:National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).CONCLUSIONS:The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe.
