Management of Urinary Stone with Potassium Citrate.
- Author:
Hyun Gon CHOI
1
;
Sung Kwang CHUNG
;
Yoen Kyu PARK
Author Information
1. Department of Urology, Kyungpook National University, School of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Urinary stone;
Management;
Potassium citrate
- MeSH:
Calcium;
Calcium Oxalate;
Citric Acid;
Crystallization;
Humans;
Hydrogen-Ion Concentration;
Nephrolithiasis;
Oxalic Acid;
Phosphorus;
Potassium Citrate*;
Potassium*;
Solubility;
Uric Acid;
Urinary Calculi*
- From:Korean Journal of Urology
1995;36(7):731-735
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Potassium citrate therapy caused a sustained increase in urinary pH and potassium, and restored urinary citrate to normal levels. No significant changes occurred in urinary uric acid, oxalate, sodium or phosphorus levels. Owing to these physiological changes, uric acid solubility increased, urinary saturation of calcium oxalate decreased and the propensity for spontaneous nucleation of calcium oxalate was reduced to normal. Therefore, the Physicochemical environment of urine following treatment become less conductive to the crystallization of calcium oxalate or uric acid. Twenty six patients with uric acid nephrolithiasis with or without calcium nephrolithiasis underwent treatment and long-term preventive management (mean of 20.8 months) with potassium citrate. Urinary pH increased from acid (5.0-5.5) to normal (6.5-7.0) during treatment. During the period of preventive management, stones were not developed.
