Gastrointestinal cancer influenced by genetic effect of cancer history of first-degree relatives
10.19428/j.cnki.sjpm.2018.18974
- VernacularTitle:一级亲属癌症史对胃肠道癌症的遗传倾向影响
- Author:
Na LIU
1
;
Lin-Chi WANG
;
Yi-He HU
;
Yan LU
;
Qiao-Liang HUANG
;
Li-Ling CHEN
Author Information
1. 苏州市疾病预防控制中心
- Keywords:
gastrointestinal cancer;
first-degree relative cancer history;
genetic predisposition
- From:
Shanghai Journal of Preventive Medicine
2018;30(12):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To compare the influence of first-degree relatives' cancer history on the genetic tendency of gastric and colorectal cancer. [Methods] Patients with gastric and colorectal cancer from six towns of Suzhou City were investigated by means of face-to-face survey based on the "Family History and History of Population Diseases Questionnaire"which included general conditions, family composition and cancer occurrence of all their three degree relatives. [Results] If there were first-degree relatives with history of cancer, individual risk of gastric cancer would be higher than that of colorectal cancer by 55%, with the adjusted OR (95% CI) being 1.551 (1.021, 2.356). If there were first-degree relatives with history of digestive tract cancer, the risk of the subject would increase to 104%, with the adjusted OR (95%CI) being 2.037 (1.279, 3.246). Men with first-degree relatives who had cancer history was at91% higher risk of developing gastric cancer than colorectal cancer, with the adjusted OR (95%CI) being1.911 (1.080, 3.381). And for history of digestive tract cancer, the risk would reach 156%, with the adjusted OR (95% CI) being 2.559 (1.337, 4.897). The number of cancers suffered by first-degree relatives of those patients with gastric cancer was higher than that of patients with colorectal cancer, with Z =-6.873, P<0.001, while the number of digestive tract cancer was also higher, with Z =-6.137, P<0.001. [Conclusion] The history of cancer and digestive tract cancer with first-degree relatives, is more common in patients with gastric cancer than with colorectal cancer. It is necessary to focus health education on men with first-degree relatives suffering from cancer or digestive tract cancer and suggest some changes in their living habits and regular medical examinations to reduce the occurrence of gastric cancer.