Drug resistance analysis on smear-positive pulmonary tuberculosis in Taizhou City from 2015 to 2017
10.19428/j.cnki.sjpm.2018.18817
- VernacularTitle:台州市2015—2017年涂阳肺结核病例耐药性分析
- Author:
Yuan-Yuan XU
1
;
Xiao-Xiao CHEN
;
Xi-Kai CHEN
;
Wei-Wei SHEN
;
Ke-Ran WANG
;
Hai-Jiang LIN
Author Information
1. 台州市疾病预防控制中心
- Keywords:
tuberculosis;
drug resistance;
monitor
- From:
Shanghai Journal of Preventive Medicine
2018;30(12):1012-1015
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To ascertain the drug resistance for pulmonary tuberculosis in Taizhou City, and to provide basis for tuberculosis prevention and control strategy. [Methods] The sputum samples were collected form 267 smear positive pulmonary tuberculosis patients who registered in a drug susceptibility testing (DST) monitoring site in Taizhou City form 2015 to 2017. Then with culture, identification of Mycobacterium and DST for 9 anti-tuberculosis drugs [isoniazid (INH) , rifampicin (RFP) , ethambutanol (EMB) , streptomycin (SM) , kanamycin (KAM) , ofloxacin (OFX) , crinkledmycin (CPM) , promethylamine (PTO) and para amino salicylate (PAS) ] by using proportion method performed on all sputum specimens. [Results]Of the 267 smear positive cases, 220 were cultured with 190 culture positive (17 were identified as nontuberculous mycobacterial infections) , 28 culture negative, and 2contaminated. Among 160 cases with the result of DST to 9 drugs, the overall drug resistance rate was22.5%. The overall drug resistance rates were 21.4% and 33.3% in the newly diagnosed patients and retreated patients respectively. There was no significant difference between the two groups (P>0.05). The multidrug resistance rate was 3.1%, and had a significant difference between the new and retreated patients (0.7% vs. 26.7%, P<0.01). Drug resistances rates of the 9 drugs ranged from high to low as:INH (8.1%) , PTO (8.1%) , SM (6.9%) , RFP (6.3%) , OFX (2.5%) , PAS (2.5%) , EMB (2.5%) , CPM (2.5%) and KAM (2.5%). There was no gender difference found in drug resistance rates (P> 0.05). Neither was there age difference (P> 0.05). [Conclusion] The epidemic of drugresistant of tuberculosis in Taizhou City are still high, especially that of acquired multi-drug resistance of tuberculosis. We must continue to improve the "three-in-one"management model, improve the quality of clinical diagnosis and treatment, and strengthen community medication management.