Risk factors and prophylactic strategies of hepatitis B virus vertical transmission
- VernacularTitle:乙型肝炎病毒垂直传播的危险因素和预防策略
- Author:
Min LIU
1
;
Zi-Xiong LI
;
Wei LU
;
Huai-Fang LI
;
Guang-Wen CAO
Author Information
1. 同济大学附属同济医院妇产科
- Keywords:
Hepatitis B virus;
vertical transmission;
chronic infection;
immune blocking
- From:
Shanghai Journal of Preventive Medicine
2016;28(7):464-468
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B virus ( HBV) infection is a principal risk factor for liver cirrhosis and hepatocellular carcinoma in China , representing one of the major public health problems .Horizontal trans-mission of HBV in vaccinated children was greatly reduced due to widespread HBV vaccination in mainland China, which had limited effects on vertical transmission .Thus, vertical transmission became one of the main causes of HBV chronic infection .High HBV load (≥10 6 copies/mL ) and hepatitis B e antigen ( HBeAg )-positivity in maternal peripheral blood were independent risk factors for HBV intrauterine infection .Compared to HBV infection in early childhood and in adult , intrauterine HBV infection was more prone to developing chronic infection .To decrease vertical transmission of HBV , we recommend that young pregnant women with sero-positive for HBeAg and high serum HBV DNA level should receive antiviral treatment with nucleotide analogues since the 28 th gestation weeks .For newborns born to HBeAg-positive mother , hepatitis B immunoglobulin ( HBIG ) injection should be administrated in combination with HBV vaccination .
