Comparison of two chemiluminescence systems used in the measurement of plasma aldosterone and renin concentrations
10.3760/cma.j.issn.1674-6090.2019.05.013
- VernacularTitle:两种化学发光检测系统检测血浆醛固酮和肾素浓度的比较
- Author:
Xiuyong YANG
1
;
Fengfan ZHENG
;
Ying SONG
;
Shumin YANG
;
Jinbo HU
;
Wenwen HE
;
Zhi-Hong WANG
;
Qingfeng CHENG
;
Qifu LI
Author Information
1. 重庆医科大学附属第一医院内分泌科
- Keywords:
Aldosterone;
Renin;
Chemiluminescent assays;
Reference interval
- From:
Chinese Journal of Endocrine Surgery
2019;13(5):413-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the imported (Diasorin,Italy) and domestic (Mindray,Shenzhen) chemiluminescent systems used in the measurement of plasma aldosterone and renin concentrations;To establish the reference interval of plasma aldosterone and renin concentrations in healthy adults.Methods With the assay instrument and its kits from Italy Diasorin as the reference system,the concentrations of plasma aldosterone and renin were measured by the two systems,in 143 healthy adults,72 patients with hypertension (16 patients with primary aldosteronism) and to establish the medical reference range (P2.5-P97.5) of them.Results The plasma aldosterone (r=0.914,P＜0.01) and renin(r=0.977,P＜0.01)concentrations detected by the two systems were positively correlated.Distribution of plasma aldosterone and renin was skewed in healthy adults.The reference interval was 30.8-344.6 pg/ml for aldosterone and 2.4-90.0 μIU/ml for renin by the imported chemiluminescent system.The reference interval was 29.4-473.3 pg/ml for aldosterone and 3.6-98.3 μIU/ml for renin by the domestic chemiluminescent detection system.Conclusion The two systems are closely correlated in measuring plasma aldosterone and renin concentrations.
