Research progress on diagnosis and application value of CSF exosome in CNS disease

VernacularTitle:CSF外泌体在CNS疾病诊断与应用价值的研究进展
Author: Xiaoxu GE ¹ ; Qiuhong JI
Author Information

1. 226001,南通大学附属医院神经内科
Keywords: exosomes; CNS diseases; diagnostic markers; pathogenic mechanisms
From: Journal of Clinical Neurology 2019;32(5):383-386
CountryChina
Language:Chinese
Abstract: Exosomes are vesicles released into extracellular cells by fusion of intracellular polyvesicles and cell membranes. Exosomes are secreted by a variety of cells and exist in a variety of body fluids. Exosomes contain proteins, lipids and nucleic acids, which can participate in the information exchange between cells. Exosomes secreted by CNS cells are involved in the occurrence and development of CNS diseases. Recent studies have shown that exosomes can not only serve as early diagnostic markers for CNS diseases, but also have therapeutic potential for CNS diseases. In this paper, the development, diagnosis and treatment of CSF exosomes in CNS diseases were reviewed.