Research of Jiawei-Xiaoyao powder on the Ghrelin, VIP for the non-erosive reflux disease with stagnation of liver Qi and spleen deficiency type
10.3760/cma.j.issn.1673-4246.2019.08.002
- VernacularTitle:加味逍遥散对非糜烂性反流病肝郁脾虚证患者血管活性肠肽及促生长素水平的影响
- Author:
Guoqiang CAO
1
;
Zhiqiang REN
;
Fengzhe SU
Author Information
1. 北京市通州区中西医结合医院脾胃科 101100
- Keywords:
Jia Wei Xiao Yao San;
Non-erosive reflux disease;
Syndrome of stagnation of liver qi and spleen deficiency;
Somatotropin;
Vasoactive intestinal peptide
- From:
International Journal of Traditional Chinese Medicine
2019;41(8):802-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Jiawei-Xiaoyao powder on the levels of somatotropin and vasoaetive intestinal peptide (VIP) in patients with non-erosive reflux disease (NERD).Methods Seventy patients with liver-stagnation and spleen-deficiency NERD who met the inclusion criteria were divided into two groups according to the random number table,35 in each group.The treatment group was orally administered with Jiawei-Xiaoyao powder,and the control group was given oral omeprazole enteric-coated tablets and domperidone.Both groups were treated for 8 weeks.Plasma somatotropin and VIP levels were measured by ELISA.Results After treatment,plasma somatotropin levels (210.96 ± 16.85 pg/ml vs.195.75 ± 12.62 pg/ml,t=4.274) in the treatment group were significantly higher than that in the control group (P＜0.01),and plasma VIP level (16.12 ± 1.41 pg/ml vs.18.57 ± 2.68 pg/ml,t=4.786) in the treatment group was significantly lower than that in the control group (P＜0.01).Conclusions The Jiawei-Xiaoyao powder could reduce plasma VIP level in NERD patients,increase plasma somatotropin levels of NERD.
