PET probes of small molecule polypeptide immunosuppressive agents guiding tumor immunotherapy
10.3760/cma.j.issn.1673-422X.2019.08.001
- VernacularTitle:小分子多肽免疫抑制剂PET探针引导肿瘤免疫治疗新进展
- Author:
Jinquan JIANG
1
;
Teli LIU
;
Lei XIA
;
Hua ZHU
;
Zhi YANG
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科恶性肿瘤发病机制及转化研究教育部重点实验室 100142
- Keywords:
Immunosuppressive agents;
Positron-emission tomography;
Immunotherapy
- From:
Journal of International Oncology
2019;46(8):449-452
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressant targeting programmed death protein-1 and its ligand (PD-1/PD-L1) is a hot topic in solid tumor immunotherapy.Detection of PD-1/PD-L1 expression in solid tumor patients by molecular imaging can predict whether tumor patients can benefit from immunotherapy.Small molecular polypeptide inhibitors have the advantages of low molecular weight,fast diffusion in tumor microenvironment,uniform distribution and easy access to the deep part of solid tumor.Non-invasive,real-time and quantitative detection of PD-1/PD-L1 expression in tumor patients can be performed by radionuclide labeled small molecular polypeptide inhibitor molecular probe PET imaging.It is expected to provide new detection methods for patient screening,efficacy monitoring,treatment plan optimization and prognosis evaluation.
