Intrauterine infection and fetal cardiovascular system development
10.3760/cma.j.issn.1673-4408.2019.10.005
- VernacularTitle:宫内感染对胎儿心血管系统影响的研究进展
- Author:
Weiyu LIU
1
Author Information
1. 哈尔滨医科大学附属第一医院儿科
- Keywords:
Intrauterine infection;
Cardiovascular development;
Cardiac hemodynamics;
Myocardial cell damage
- From:
International Journal of Pediatrics
2019;46(10):718-721
- CountryChina
- Language:Chinese
-
Abstract:
When the pathogen infects the fetus,the pathogenic microorganism and the infection product are recognized by the corresponding receptor.The fetus innate immune system is passively activated,which produces proinflammatory cytokines,induces cascade reaction of cytokines,and releases a large number of inflammatory factors secreted by the body.Its toxic effect can cause damage to the brain,lung,small intestine and heart and other important organs of the whole body,which seriously threatens the life of the perinatal infants and their subsequent survival quality.It has been found that fetal cardiovascular system is one of the important target organs of intrauterine infection.Cytokines produced by cardiac inflammation and induced by intrauterine infection can damage myocardial cells,affect the proliferation of myocardial cells,and cause damage to cardiac function.Moreover,the persistent influence of infection on fetus leads to fetal vascular remodeling and changes in fetal cardiopulmonary hemodynamics.This article reviews the effects of pathogens of intrauterine infection and fetal cardiac inflammation,cardiac hemodynamics,cardiomyocyte development,gene program of cardiomyocyte and cardiac structure development on fetal cardiovascular system.
