Application value of NT-ProBNP and BNP in children with congenital heart disease
10.3760/cma.j.issn.1673-4408.2019.10.004
- VernacularTitle:NT-ProBNP及BNP在儿童先天性心脏病中的应用价值
- Author:
Xiaolong ZHANG
1
Author Information
1. 重庆医科大学附属儿童医院心内科 儿童发育疾病研究教育部重点实验室 儿童发育重大疾病国家国际科技合作基地 儿科学重庆市重点实验室 400014
- Keywords:
Brain natriuretic peptide;
N-terminal pro-brain natriuretic peptide;
Congenital heart disease;
Heart failure;
Perioperative period
- From:
International Journal of Pediatrics
2019;46(10):713-717
- CountryChina
- Language:Chinese
-
Abstract:
Congenital heart disease (CHD) is the most common congenital malformation and also one of the common causes of heart failure in children.At present,the clinical diagnosis of heart failure in children mainly depends on the medical history,symptoms and signs,with strong subjectivity and lack of timely and simple objective criteria,which are easy to be missed.Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-ProBNP) are polypeptides synthesized and secreted by ventricular myocytes,which have good sensitivity to reflect ventricular systolic,diastolic function and pre-and post-load.They have been widely used in various cardiovascular diseases.In recent years,many studies have shown that the plasma concentration of the two can be used to guide perioperative surgical treatment and evaluate the perioperative prognosis risk of children with CHD.This article reviews the application of BNP and NT-ProBNP in children with CHD with heart failure,especially during perioperative period.
