Role of autophagy in the pathogenesis of myocarditis
10.3760/cma.j.issn.1673-4408.2019.10.002
- VernacularTitle:自噬在心肌炎发病机制中的作用
- Author:
Honglin SUN
1
Author Information
1. 山东大学附属省立医院,济南250021
- Keywords:
Viral myocarditis;
Autophagy;
Coxsackie virus B3
- From:
International Journal of Pediatrics
2019;46(10):705-708
- CountryChina
- Language:Chinese
-
Abstract:
Myocarditis refers to diffuse or focal inflammatory cell infiltration of the myocardial interstitium and necrosis or degeneration of adjacent myocardial fiber caused by infection or other causes,which is one of the common diseases that cause the death of infants and adolescents.Viral infection is the main pathogenic factor,but the pathogenesis of myocarditis has not yet been fully elucidated.Autophagy is a highly conservative process of self-digestion,which can provide amino acids,ATP and other substances for cells in the state of inflammation or starvation to help cells survive the energy crisis under excessive stimulation.However,excessive autophagy can promote the replication of viruses,which leads to autophagic death.In recent years,some researchers found that autophagy is closely related to the process of viral myocarditis associated with Coxsackie virus B3.The role of autophagy in the pathogenesis of myocarditis is reviewed in this article.
