Mechanisms for establishment of the placental defensive barrier.
- Author:
Wan-Shan ZHENG
1
;
Xiao-Qian HU
2
;
Yan-Ling WANG
3
;
Bin CAO
4
Author Information
1. School of Medicine, Xiamen University, Xiamen 361102, China.
2. School of Public Health, Xiamen University, Xiamen 361102, China.
3. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
4. School of Medicine, Xiamen University, Xiamen 361102, China. caobin19@xmu.edu.cn.
- Publication Type:Journal Article
- From:
Acta Physiologica Sinica
2020;72(1):115-124
- CountryChina
- Language:Chinese
-
Abstract:
Placenta serves as a temporary fetal organ, which mediates maternal-fetal crosstalk and intrauterine fetal growth. Placental defensive barrier is a fundamental physiological function, which balances maternal immune tolerance to the fetus and resistance to pathogens. This review summarizes the latest research progress on the mechanisms of placental barrier formation from the view of placental development. Recent discoveries have shed light on the cellular and molecular properties of placental defensive mechanisms in syncytiotrophoblast, including autophagy, exosome mediated anti-pathogenic pathways, cell-cell junctions and cytoskeleton networks. We also present an overview of placental barrier dysfunction and its implications in intrauterine TORCH infections.
